SYNERGISTIC DNA-DAMAGING EFFECT IN MULTIPLE MYELOMA WITH THE COMBINATION OF ZALYPSIS, BORTEZOMIB AND DEXAMETHASONE

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone

Despite new advances in multiple myeloma treatment and the consequent improvement in overall survival, most patients relapse or become refractory to treatment.This suggests that new molecules and combinations that may further inhibit important survival pathways for these tumor cells are needed.In this context, zalypsis is a novel compound, derived

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Prevention of CSF leak from the spinal operation site due to either traumatic or iatrogenic injury to the Dura.

Background: Cerebrospinal fluid leak is a relatively common problem ranging from 0.5% to 18% with traumatic or incidental injury to the Dura intra-operatively1, 2.Traumatic injury mostly occurs due to mechanical trauma with subsequent thecal sac laceration mainly in the thoracolumbar region.Incidental Dural injury commonly happens in patients under

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Prototipe Sistem Informasi Retailer Industri Kreatif Di Kota Solo

Solo is a cultural city.in addition solo has some business actors in the arts and cultural arts until now still exist in production.The problems faced by UKM craft art and culture here is the lack of marketing media, therefore making the difficulty of handicraft products known by the public.Marketing media utilized include brochures, pamphlets and

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